The topic of the IRNCAS International Symposium is the retroviral nucleocapsid protein (NC) and its Gag precursor, a polyprotein responsible for the viral assembly.
This symposium represents an important opportunity in getting together the specialists and generating new collaborations and multidisciplinary studies (biophysics, biochemistry, virology, cellular biology, biomedicine and biophotonics). During the last 15 years, these collaborations have provided important progresses in the insight into the molecular and cellular mechanisms of action of the HIV-1 nucleocapsid and its Gag precursor, making them promising targets in the design of inhibitors against the AIDS epidemics.
This 10th edition should encourage the continuation of our collaborative network in order to enlighten the structural and functional properties of the NC domain of Gag during virus assembly in the host cell.
"Special attention will be given to :
Gag and cell factors interactions (membrane lipids and cellular proteins)
Gag and NC chaperone properties
The impact of the biophysical methods, notably of the high resolution microscopy and the NMR, on the understanding of Gag assembly
Therapeutic strategies targeting HIV-1 NC and Gag assembly.
The major topics discussed during this Symposium are focused on the HIV-1 nucleocapsid and on the retroviral Gag proteins, however other nucleocapsid of viruses causing human pathologies (HTLV, Hepatitis and Influenza) will be also considered."
List of invited speakers:
Bieniasz Paul*, Rockfeller University, NY, USA
Lamb Don*, University of Munich, Germany
Berkhout Ben, AMC, University of Amsterdam, Netherland Benkirane Monsef, CNRS, IGF, Montpellier, France Boris-Lawrie Kathleen,University of Minnesota, Columbus, USA Bouamr Fadila, NIAID, NIH, Bethesda, USA Briggs John, European Molecular Biology Laboratory, Germany Cimarelli Andrea, INSERM & ENS Lyon, France Cox Bryan, Emory University, USA Freed Eric, HIV Drug Resistance Program, NCI-Frederick, USA Favard Cyril, CNRS, CPBS, Montpellier, France Lever Andrew, University of Cambridge, UK Marquet Roland, CNRS & IBMC, Strasbourg, France Mély Yves, Université de Strasbourg & CNRS, France Merchant Jan, HHMI & University of Maryland, Baltimore, USA Mirambeau Gilles, UPMC & Hospital Clinic-IDIBAPS, France & Spain Milhiet Pierre-Emmanuel, CBS Montpellier, France Mouland Andrew, Mc Gill University, Montreal, Canada Mori Mattia, Siena University, Italy Müller Barbara, University Hospital, Heidelberg, Germany Muriaux Delphine, CNRS, CPBS Montpellier, France Musier-Forsyth Karin, Ohio State University, Columbus, USA Ohlmann Theophile, INSERM & ENS Lyon, France Rein Alan, HIV Drug Resistance Program, NCI-Frederick, USA de Rocquigny Hugues, CNRS & Université de Strasbourg, France Saad Jamil, University of Alabama, Birmingham, USA Schwartz Olivier, Institut Pasteur, France Spearman Paul, Emory University,USA Tisné Carine, CNRS & Université Paris Descartes, France Williams Mark, Northeastern University, Boston, USA
Ben Berkhout, University of Amsterdam, Netherlands Andrew Mouland, McGill University, Canada Yves Mély, France, Université de Strasbourg, France Mark Williams, Northeastern University, Boston, USA Leslie Parent, Penn State University, Hershey, USA Mike Summers, JHopkins University, Baltimore, USA Fadila Bouamr, NIH, Bethesda, USA Gilles Mirambeau, IDIBAPS, Barcelona, Spain
This 10th edition is co-organized by:
D. Muriaux (Montpellier, FR), H. de Rocquigny (Strasbourg, FR),C. Favard (Montpellier, FR), C. Mariani-Floderer (Montpellier, FR), E.O Freed (NIH Frederick, USA), K. Musier-Forsyth (Ohio, USA).